Prediction of a ligand-binding niche within a human olfactory receptor by combining site-directed mutagenesis with dynamic homology modeling

Angew Chem Int Ed Engl. 2012 Jan 27;51(5):1274-8. doi: 10.1002/anie.201103980. Epub 2011 Dec 5.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Humans
  • Ligands
  • Models, Molecular
  • Molecular Dynamics Simulation
  • Mutagenesis, Site-Directed
  • Protein Binding
  • Receptors, Odorant / chemistry*
  • Receptors, Odorant / genetics
  • Structural Homology, Protein
  • Structure-Activity Relationship

Substances

  • Ligands
  • OR2AG1 protein, human
  • Receptors, Odorant