Synthesis of a biologically active triazole-containing analogue of cystatin A through successive peptidomimetic alkyne-azide ligations

Angew Chem Int Ed Engl. 2012 Jan 16;51(3):718-22. doi: 10.1002/anie.201107222. Epub 2011 Dec 5.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry
  • Amino Acid Sequence
  • Azides / chemistry
  • Cathepsins / antagonists & inhibitors
  • Cell Line, Tumor
  • Click Chemistry / methods*
  • Cyclization
  • Cystatin A / chemical synthesis*
  • Cystatin A / chemistry
  • Cystatin A / pharmacology*
  • Humans
  • Molecular Sequence Data
  • Neoplasm Invasiveness / prevention & control
  • Peptidomimetics / chemistry*
  • Triazoles / chemical synthesis
  • Triazoles / chemistry*

Substances

  • Alkynes
  • Azides
  • Cystatin A
  • Peptidomimetics
  • Triazoles
  • Cathepsins