Abstract
Credneramides A (1) and B (2), two vinyl chloride-containing metabolites, were isolated from a Papua New Guinea collection of cf. Trichodesmium sp. nov. and expand a recently described class of vinyl chloride-containing natural products. The precursor fatty acid, credneric acid (3), was isolated from both the aqueous and organic fractions of the parent fraction as well as from another geographically and phylogenetically distinct cyanobacterial collection (Panama). Credneramides A and B inhibited spontaneous calcium oscillations in murine cerebrocortical neurons at low micromolar concentrations (1, IC(50) 4.0 μM; 2, IC(50) 3.8 μM).
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Amines / chemistry
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Amines / isolation & purification*
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Amines / pharmacology*
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Animals
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Base Sequence
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Cyanobacteria
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Fatty Acids / chemistry*
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Fatty Acids / isolation & purification
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Fatty Acids / pharmacology*
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Mice
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Molecular Structure
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Neurotransmitter Agents / chemistry
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Neurotransmitter Agents / isolation & purification*
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Neurotransmitter Agents / pharmacology*
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Papua New Guinea
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Phenethylamines / chemistry
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Phenethylamines / isolation & purification
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Phenethylamines / pharmacology*
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Quorum Sensing / physiology
Substances
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Amines
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Fatty Acids
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Neurotransmitter Agents
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Phenethylamines
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credneramide A
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credneramide B