Lock and key to transcription: σ-DNA interaction

Xin Liu; David A Bushnell; Roger D Kornberg

doi:10.1016/j.cell.2011.11.033

Lock and key to transcription: σ-DNA interaction

Cell. 2011 Dec 9;147(6):1218-9. doi: 10.1016/j.cell.2011.11.033.

Authors

Xin Liu¹, David A Bushnell, Roger D Kornberg

Affiliation

¹ Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

PMID: 22153066
DOI: 10.1016/j.cell.2011.11.033

Abstract

How does RNA polymerase recognize a promoter in duplex DNA? How are the DNA strands pried apart to enable RNA synthesis? A crystal structure by Feklistov and Darst unexpectedly reveals that these two processes are interconnected.

Publication types

Comment