A partner evokes latent differences between Hox proteins

Aseem Z Ansari; Kimberly J Peterson-Kaufman

doi:10.1016/j.cell.2011.11.046

A partner evokes latent differences between Hox proteins

Cell. 2011 Dec 9;147(6):1220-1. doi: 10.1016/j.cell.2011.11.046.

Authors

Aseem Z Ansari¹, Kimberly J Peterson-Kaufman

Affiliation

¹ Department of Biochemistry and The Genome Center, University of Wisconsin, Madison, Madison, WI 53706, USA. [email protected]

PMID: 22153067
DOI: 10.1016/j.cell.2011.11.046

Abstract

Hox transcription factors bind highly related DNA sequences in vitro, yet they regulate different genes and play distinct roles in anterior-posterior patterning in animals. Slattery et al. report that a common cofactor, Exd, accentuates latent sequence specificities of all eight Hox proteins and directs binding to relevant sites across the genome.

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