Abstract
The advent of combination antiretroviral treatment has had a profound impact on CNS HIV infection and its clinical complications, but neurological impairment still occurs in patients on systemically effective combination therapy, and in some patients it may be important to consider antiretroviral drug entry and effects within the CNS. There are now data on the CNS exposure for most antiretroviral drugs. This review focuses on the CNS pharmacokinetics and pharmacodynamics of antiretroviral drugs in humans, and also discusses controversies in this field.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Anti-HIV Agents / administration & dosage*
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Anti-HIV Agents / pharmacokinetics
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Anti-HIV Agents / pharmacology
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Anti-Retroviral Agents / administration & dosage*
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Anti-Retroviral Agents / pharmacokinetics
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Anti-Retroviral Agents / pharmacology
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Encephalitis, Viral / drug therapy*
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Encephalitis, Viral / virology
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HIV Infections / complications*
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HIV Infections / drug therapy*
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HIV Infections / virology
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HIV-1 / isolation & purification
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Humans
Substances
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Anti-HIV Agents
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Anti-Retroviral Agents