[Advantages and prospects of the use of genetic vaccines for the protection from dangerous and socially significant infections]

Vestn Ross Akad Med Nauk. 2011:(10):39-47.
[Article in Russian]

Abstract

High frequency of epidemiological threats (H5N1 influenza, SARS, etc.) in modern world calls for the development of new flexible technologies for manufacturing efficacious vaccines and rapid reorientation of their production as appropriate. Genetic vaccination is one of such technologies aimed at prophylaxis of dangerous and socially significant infections. The technology is based on administration of one or several functionally active genes encoding for antigens of pathogens which induces formation of both cellular and humoral immunity against the respective microorganism. This property of genetic vaccines is used for the development of prophylactic schemes. New vaccines are currently being designed to prevent a variety of infections. The aim of the present review is to outline major trends in genetic vaccination leading to the improvement of its efficacy.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Biological Availability
  • Communicable Disease Control / methods
  • Communicable Disease Control / trends*
  • Forecasting
  • Humans
  • Immunization, Passive* / methods
  • Immunization, Passive* / trends
  • Immunotherapy, Active* / methods
  • Immunotherapy, Active* / trends
  • Influenza A Virus, H5N1 Subtype* / genetics
  • Influenza A Virus, H5N1 Subtype* / immunology
  • Influenza, Human* / prevention & control
  • Influenza, Human* / virology
  • Severe Acute Respiratory Syndrome* / prevention & control
  • Severe Acute Respiratory Syndrome* / virology
  • Severe acute respiratory syndrome-related coronavirus* / genetics
  • Severe acute respiratory syndrome-related coronavirus* / immunology
  • Vaccines, DNA / genetics
  • Vaccines, DNA / pharmacokinetics
  • Vaccines, Virosome / genetics
  • Vaccines, Virosome / pharmacokinetics

Substances

  • Vaccines, DNA
  • Vaccines, Virosome