Diterpenoids including a novel dimeric conjugate from Salvia leriaefolia

Planta Med. 2012 Feb;78(3):269-75. doi: 10.1055/s-0031-1280454. Epub 2011 Dec 15.

Abstract

Salvialeriafone (1), a novel diterpene-norditerpene conjugate, was isolated from Salvia leriaefolia. Additionally, two new abietane-type diterpenoids, salvialerial (2) and salvialerione (3), as well as four known compounds, sugiol (4), salvicanaric acid (5), dehydroroyleanone (6), and cariocal (7), were isolated and identified. Their structures were determined by spectroscopic data analyses. Known compounds were isolated from this plant for the first time. Compounds 1, 5, 6, and 7 exhibited IN VITRO antiproliferative activity against the human cervical cancer cell line (Hela), while 6 showed cytotoxicity against the human prostate cancer cell line (PC3).

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Diterpenes / chemistry*
  • Diterpenes / pharmacology
  • HeLa Cells
  • Humans
  • Iran
  • Male
  • Molecular Structure
  • Phytotherapy
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plant Roots / chemistry
  • Prostatic Neoplasms / drug therapy
  • Salvia / chemistry*

Substances

  • Antineoplastic Agents, Phytogenic
  • Diterpenes
  • Plant Extracts
  • sugiol