Kaposi's sarcoma herpesvirus oncogenesis is a notch better in 3D

Enrique A Mesri; Ethel Cesarman

doi:10.1016/j.chom.2011.11.008

Kaposi's sarcoma herpesvirus oncogenesis is a notch better in 3D

Cell Host Microbe. 2011 Dec 15;10(6):529-31. doi: 10.1016/j.chom.2011.11.008.

Authors

Enrique A Mesri¹, Ethel Cesarman

Affiliation

¹ Viral Oncology Program, Sylvester Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA. [email protected]

Abstract

Culture of KSHV-infected lymphatic endothelial cells in 3D increases viral gene expression, leading to Notch-induced MT1-MMP-dependent endothelial-to-mesenchymal transition. This reproduces patterns of KSHV gene expression and presence of mesenchymal KSHV-infected cells found in KS lesions, narrowing the gap between in vitro systems of infection and KSHV tumorigenesis.

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