Human endometrial-derived mesenchymal stem cells suppress inflammation in the central nervous system of EAE mice

Stem Cell Rev Rep. 2012 Sep;8(3):940-52. doi: 10.1007/s12015-011-9338-3.

Authors

J P S Peron¹, T Jazedje, W N Brandão, P M Perin, M Maluf, L P Evangelista, S Halpern, M G Nisenbaum, C E Czeresnia, M Zatz, N O S Câmara, L V Rizzo

Affiliation

¹ Transplantation Immunobiology Lab - the Department of Immunology - Institute of Biomedical Sciences IV, University of São Paulo, Rua Prof. Dr. Lineu Prestes 1730 Cidade Universitária, São Paulo, SP, Brazil CEP 05508-900.

PMID: 22180029
DOI: 10.1007/s12015-011-9338-3

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adipogenesis
Animals
Antigens, CD / metabolism
Cells, Cultured
Central Nervous System / immunology
Central Nervous System / pathology*
Encephalomyelitis, Autoimmune, Experimental / immunology
Encephalomyelitis, Autoimmune, Experimental / pathology
Encephalomyelitis, Autoimmune, Experimental / therapy*
Endometrium / pathology*
Female
Forkhead Transcription Factors / metabolism
Gene Expression
Humans
Inflammation
Interleukin-10 / genetics
Interleukin-10 / metabolism
Interleukins / genetics
Interleukins / metabolism
Mesenchymal Stem Cell Transplantation*
Mesenchymal Stem Cells / metabolism
Mesenchymal Stem Cells / physiology*
Mice
Mice, Inbred C57BL
Phenotype
Th1 Cells / pathology
Th17 Cells / pathology

Substances

Antigens, CD
Forkhead Transcription Factors
Foxp3 protein, mouse
IL10 protein, mouse
Il27 protein, mouse
Interleukins
Interleukin-10