Gene therapy restores missing cone-mediated vision in the CNGA3-/- mouse model of achromatopsia

Adv Exp Med Biol. 2012:723:183-9. doi: 10.1007/978-1-4614-0631-0_25.

Authors

Stylianos Michalakis¹, Regine Mühlfriedel, Naoyuki Tanimoto, Vidhyasankar Krishnamoorthy, Susanne Koch, M Dominik Fischer, Elvir Becirovic, Lin Bai, Gesine Huber, Susanne C Beck, Edda Fahl, Hildegard Büning, Jennifer Schmidt, Xiangang Zong, Tim Gollisch, Martin Biel, Mathias W Seeliger

Affiliation

¹ Department of Pharmacy, Center for Integrated Protein Science Munich (CIPSM), Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany.

PMID: 22183332
DOI: 10.1007/978-1-4614-0631-0_25

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Color Vision / genetics
Color Vision Defects / genetics*
Color Vision Defects / therapy*
Cyclic Nucleotide-Gated Cation Channels / genetics*
Dependovirus / genetics
Electroretinography
Genetic Therapy / methods*
HEK293 Cells
Humans
Mice
Recombinant Proteins / genetics
Recovery of Function / genetics
Retinal Cone Photoreceptor Cells / physiology*
Retinal Rod Photoreceptor Cells / physiology

Substances

Cnga3 protein, mouse
Cyclic Nucleotide-Gated Cation Channels
Recombinant Proteins

Supplementary concepts

Achromatopsia 2