Targeting the angiopoietin/Tie2 pathway: cutting tumor vessels with a double-edged sword?

J Clin Oncol. 2012 Feb 1;30(4):441-4. doi: 10.1200/JCO.2011.38.7621. Epub 2011 Dec 19.
No abstract available

Publication types

  • Review

MeSH terms

  • Angiogenesis Inhibitors / pharmacology*
  • Angiogenesis Inhibitors / therapeutic use
  • Angiopoietins / antagonists & inhibitors*
  • Angiopoietins / metabolism
  • Animals
  • Humans
  • Molecular Targeted Therapy
  • Neoplasms / blood supply*
  • Neoplasms / drug therapy*
  • Neoplasms / metabolism
  • Neovascularization, Pathologic / drug therapy
  • Neovascularization, Pathologic / metabolism
  • Receptor, TIE-2 / antagonists & inhibitors*
  • Receptor, TIE-2 / metabolism
  • Signal Transduction / drug effects

Substances

  • Angiogenesis Inhibitors
  • Angiopoietins
  • Receptor, TIE-2