Regioselective base-free intermolecular aminohydroxylations of hindered and functionalized alkenes

J Org Chem. 2012 Jan 20;77(2):1208-14. doi: 10.1021/jo202375a. Epub 2012 Jan 4.

Abstract

Regioselective base-free intermolecular aminohydroxylations of functionalized trisubstituted and 1,1-disubstituted alkenes employing benzoyloxycarbamate 3a and catalytic OsO(4) are described. In all cases, the more substituted alcohol isomer is favored. Sluggish reactions could be promoted by gentle heating, the use of amine ligands, or increased catalyst loadings. A competitive rearrangement was observed with a secondary allylic alcohol substrate. The adducts serve as useful precursors to dehydroamino acids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemical synthesis
  • Alkenes / chemistry*
  • Amines / chemistry
  • Amino Alcohols / chemistry
  • Catalysis
  • Chemistry Techniques, Synthetic
  • Ligands
  • Molecular Structure
  • Stereoisomerism

Substances

  • Alkenes
  • Amines
  • Amino Alcohols
  • Ligands