Cellulose synthase interactive protein 1 (CSI1) links microtubules and cellulose synthase complexes

Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):185-90. doi: 10.1073/pnas.1118560109. Epub 2011 Dec 21.

Abstract

Cellulose synthase (CESA) complexes can be observed by live-cell imaging to move with trajectories that parallel the underlying cortical microtubules. Here we report that CESA interactive protein 1 (CSI1) is a microtubule-associated protein that bridges CESA complexes and cortical microtubules. Simultaneous in vivo imaging of CSI1, CESA complexes, and microtubules demonstrates that the association of CESA complexes and cortical microtubules is dependent on CSI1. CSI1 directly binds to microtubules as demonstrated by in vitro microtubule-binding assay.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Arabidopsis / cytology
  • Arabidopsis / drug effects
  • Arabidopsis / enzymology*
  • Arabidopsis Proteins / metabolism*
  • Carrier Proteins / metabolism*
  • Dinitrobenzenes / pharmacology
  • Glucosyltransferases / metabolism*
  • Microtubules / drug effects
  • Microtubules / enzymology*
  • Multienzyme Complexes / metabolism*
  • Protein Binding / drug effects
  • Protein Transport / drug effects
  • Sulfanilamides / pharmacology
  • Time Factors

Substances

  • Arabidopsis Proteins
  • CSI1 protein, Arabidopsis
  • Carrier Proteins
  • Dinitrobenzenes
  • Multienzyme Complexes
  • Sulfanilamides
  • oryzalin
  • Glucosyltransferases
  • cellulose synthase