Abstract
Mitochondria are the power plant of the heart, burning fat and sugars to supply the muscle with the adenosine triphosphate (ATP) free energy that drives contraction and relaxation during each heart beat. This function was first captured in a mathematical model in 1967. Today, interest in such a model has been rekindled by ongoing in silico integrative physiology efforts such as the Cardiac Physiome project. Here, the status of the field of computational modeling of mitochondrial ATP synthetic function is reviewed.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Adenosine Diphosphate / metabolism
-
Adenosine Triphosphatases / metabolism
-
Adenosine Triphosphate / metabolism*
-
Animals
-
Computer Simulation*
-
Energy Metabolism / physiology*
-
Energy Transfer*
-
Mammals
-
Mitochondria / metabolism*
-
Models, Biological*
-
Oxidation-Reduction
-
Phosphorylation / physiology
-
Reactive Oxygen Species / metabolism
Substances
-
Reactive Oxygen Species
-
Adenosine Diphosphate
-
Adenosine Triphosphate
-
Adenosine Triphosphatases