Novel, nonreflex tests detect analgesic action in rodents at clinically relevant concentrations

Ann N Y Acad Sci. 2011 Dec:1245:11-3. doi: 10.1111/j.1749-6632.2011.06342.x.

Abstract

We propose that predictive validity of tests for analgesia may be improved by looking to reinstate specific, innate behaviors suppressed by pain, e.g., burrowing, because effective plasma concentrations in the rat are closer to effective clinical plasma concentrations than those generally used in rodent reflex withdrawal assays.

Publication types

  • Comparative Study

MeSH terms

  • Analgesics / administration & dosage*
  • Analgesics, Non-Narcotic / administration & dosage
  • Animals
  • Behavior, Animal / drug effects
  • Behavior, Animal / physiology
  • Chronic Pain / drug therapy
  • Chronic Pain / physiopathology
  • Freund's Adjuvant / toxicity
  • Humans
  • Ibuprofen / administration & dosage
  • Pain Measurement / methods*
  • Rats
  • Reflex / drug effects
  • Reflex / physiology
  • Reproducibility of Results
  • Species Specificity

Substances

  • Analgesics
  • Analgesics, Non-Narcotic
  • Freund's Adjuvant
  • Ibuprofen