Self-fluorescence of chemically crosslinked MRI nanoprobes to enable multimodal imaging of therapeutic cells

Small. 2012 Mar 12;8(5):666-70. doi: 10.1002/smll.201102361. Epub 2012 Jan 5.

Abstract

Old chemistry for novel materials: Self-fluorescent high-relaxivity T(2)-weighted magnetic resonance imaging (MRI) contrast agents are produced. They are a novel type of MR/optical dual-modality in vivo imaging nanoprobe using glutaraldehyde crosslinking chemistry, and they are used to label and monitor therapeutic cells both in vitro and in vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Contrast Media / chemistry*
  • Dendritic Cells / cytology
  • Dendritic Cells / metabolism
  • Diagnostic Imaging / methods*
  • Fluorescence*
  • Glutaral / chemistry
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Nanogels
  • Polyethylene Glycols / chemistry*
  • Polyethyleneimine / chemistry*
  • Polymers / chemistry*

Substances

  • Contrast Media
  • Nanogels
  • Polymers
  • polyethylene glycol polyethyleneimine nanogel
  • Polyethylene Glycols
  • Polyethyleneimine
  • Glutaral