Molecular view on PRR cross-talk in antifungal immunity

Cell Microbiol. 2012 Apr;14(4):467-74. doi: 10.1111/j.1462-5822.2012.01748.x. Epub 2012 Feb 14.

Abstract

The identification of a major class of innate immune receptors, termed pattern recognition receptors (PRRs), has boosted research on innate pathogen recognition. The immune response to a specific pathogen is not restricted to the recognition by one type of PRR or activation of a single cell type, but instead comprises complex collaborations between different receptors, cells and signal mediators. Here we will discuss the cross-talk between PRRs involved in fungal recognition, focusing on the molecular interactions occurring at the plasma membrane.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Candida albicans / immunology*
  • Candida albicans / pathogenicity
  • Candidiasis / immunology
  • Candidiasis / microbiology
  • DEAD Box Protein 58
  • DEAD-box RNA Helicases / immunology
  • Host-Pathogen Interactions*
  • Humans
  • Immunity, Innate*
  • Lectins, C-Type / immunology
  • Nod2 Signaling Adaptor Protein / immunology
  • Receptor Cross-Talk*
  • Receptors, Immunologic
  • Signal Transduction
  • Toll-Like Receptors / immunology

Substances

  • Lectins, C-Type
  • NOD2 protein, human
  • Nod2 Signaling Adaptor Protein
  • Receptors, Immunologic
  • Toll-Like Receptors
  • RIGI protein, human
  • DEAD Box Protein 58
  • DEAD-box RNA Helicases