Agranulocytosis induced by proton pump inhibitors

J Clin Gastroenterol. 2012 Nov-Dec;46(10):859. doi: 10.1097/MCG.0b013e318236f18a.

Abstract

We report the first published case of agranulocytosis induced by omeprazole and its recurrence with esomeprazole, the S-isomer form of omeprazole. Interestingly, we found an homozygotous mutation of CYP2C19*17, responsible for the metabolism of proton pump inhibitors.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Agranulocytosis / chemically induced*
  • Agranulocytosis / genetics*
  • Aryl Hydrocarbon Hydroxylases / genetics
  • Cystic Fibrosis / complications
  • Cystic Fibrosis / genetics
  • Cytochrome P-450 CYP2C19
  • Esomeprazole / adverse effects
  • Gastroesophageal Reflux / complications
  • Gastroesophageal Reflux / drug therapy*
  • Humans
  • Male
  • Mutation
  • Omeprazole / adverse effects
  • Proton Pump Inhibitors / adverse effects*
  • Young Adult

Substances

  • Proton Pump Inhibitors
  • Aryl Hydrocarbon Hydroxylases
  • CYP2C19 protein, human
  • Cytochrome P-450 CYP2C19
  • Omeprazole
  • Esomeprazole