Abstract
PC-1505 is a C34 peptide derived from the heptad repeat 2 region of HIV-1 gp41 conjugated to human serum albumin for sustained in vivo activity. One single preexposure dose of PC-1505 reduced viral RNA in HIV-1-infected SCID-hu Thy/Liv mice by 3.3 log₁₀ and protected T cells from virus-mediated depletion. In contrast, a single preexposure dose of Truvada reduced viral RNA by only 0.8 log₁₀ and was substantially less effective in preventing T cell depletion.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Deoxycytidine / analogs & derivatives
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Deoxycytidine / pharmacology
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Dose-Response Relationship, Drug
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Drug Combinations
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Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination
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Genes, MHC Class I / genetics
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HIV Core Protein p24 / blood
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HIV Fusion Inhibitors / chemistry
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HIV Fusion Inhibitors / pharmacology*
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HIV Infections / prevention & control*
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HIV Infections / virology
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Mice
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Mice, SCID
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Organophosphorus Compounds / pharmacology
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Peptides / chemistry
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Peptides / pharmacology*
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RNA, Viral / blood
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Thymocytes / drug effects
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Thymocytes / metabolism
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Thymocytes / virology
Substances
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Drug Combinations
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Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination
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HIV Core Protein p24
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HIV Fusion Inhibitors
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Organophosphorus Compounds
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PC 1505
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Peptides
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RNA, Viral
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Deoxycytidine