Abstract
Two new pentacyclic triterpenes named kirmanoic acid (1) and kurramanoic acid (2) have been isolated from the chloroform-soluble portion of the whole plant of Nepeta clarkei Hook. The structures of the two new compounds were assigned on the basis of their ¹H and ¹³C NMR spectra including two-dimensional NMR techniques such as COSY, HMQC, and HMBC experiments. Kirmanoic acid (1) was investigated for analgesic, anti-inflammatory, and CNS depressant activities. Interestingly kirmanoic acid (1) showed strong analgesic activity than standard drug in acetic induced writhing and formalin tests. Similarly kirmanoic acid (1) also showed strong anti-inflammatory activity than its standard drug. The gross behavioral study of kirmanoic acid (1) revealed that it exhibited mild CNS stimulant and muscle relaxant in the mice. Compound 1 showed a slight increase in Locomotor activity and possesses the antidepressant effect.
Copyright © 2012 Elsevier B.V. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Acetic Acid
-
Analgesics / isolation & purification
-
Analgesics / pharmacology
-
Analgesics / therapeutic use*
-
Animals
-
Anti-Inflammatory Agents / isolation & purification
-
Anti-Inflammatory Agents / pharmacology
-
Anti-Inflammatory Agents / therapeutic use*
-
Antidepressive Agents / isolation & purification
-
Antidepressive Agents / pharmacology
-
Antidepressive Agents / therapeutic use
-
Behavior, Animal / drug effects*
-
Central Nervous System Depressants / isolation & purification
-
Central Nervous System Depressants / pharmacology
-
Central Nervous System Depressants / therapeutic use*
-
Central Nervous System Stimulants / isolation & purification
-
Central Nervous System Stimulants / pharmacology
-
Central Nervous System Stimulants / therapeutic use
-
Formaldehyde
-
Male
-
Mice
-
Mice, Inbred Strains
-
Molecular Structure
-
Nepeta / chemistry*
-
Neuromuscular Agents / isolation & purification
-
Neuromuscular Agents / pharmacology
-
Neuromuscular Agents / therapeutic use
-
Pain / chemically induced
-
Pain / drug therapy
-
Phytotherapy*
-
Plant Extracts / chemistry
-
Plant Extracts / pharmacology
-
Plant Extracts / therapeutic use
-
Rats
-
Rats, Wistar
-
Triterpenes / chemistry
-
Triterpenes / isolation & purification
-
Triterpenes / pharmacology
-
Triterpenes / therapeutic use*
Substances
-
Analgesics
-
Anti-Inflammatory Agents
-
Antidepressive Agents
-
Central Nervous System Depressants
-
Central Nervous System Stimulants
-
Neuromuscular Agents
-
Plant Extracts
-
Triterpenes
-
kirmanoic acid
-
Formaldehyde
-
Acetic Acid