Abstract
Although aberrant DNA methylation is considered to be one of the key ways by which tumor-suppressor and DNA-repair genes are silenced during tumor initiation and progression, the mechanisms underlying DNA methylation alterations in cancer remain unclear. Here we show that prostaglandin E(2) (PGE(2)) silences certain tumor-suppressor and DNA-repair genes through DNA methylation to promote tumor growth. These findings uncover a previously unrecognized role for PGE(2) in the promotion of tumor progression.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Line, Tumor
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DNA (Cytosine-5-)-Methyltransferase 1
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DNA (Cytosine-5-)-Methyltransferases / metabolism
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DNA Methylation / drug effects*
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DNA Methyltransferase 3B
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DNA Repair / drug effects
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Dinoprostone / pharmacology*
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Gene Expression Regulation, Neoplastic / physiology
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Genes, Tumor Suppressor / drug effects
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Humans
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Intestinal Neoplasms / metabolism*
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Intestinal Neoplasms / physiopathology
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Mice
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Up-Regulation
Substances
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DNA (Cytosine-5-)-Methyltransferase 1
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DNA (Cytosine-5-)-Methyltransferases
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Dinoprostone