Inferential NMR/X-ray-based structure determination of a dibenzo[a,d]cycloheptenone inhibitor-p38α MAP kinase complex in solution

Angew Chem Int Ed Engl. 2012 Mar 5;51(10):2359-62. doi: 10.1002/anie.201105241. Epub 2012 Jan 24.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Crystallography, X-Ray
  • Cycloheptanes / chemistry*
  • Dibenzocycloheptenes / chemistry
  • Enzyme Inhibitors / chemistry*
  • Magnetic Resonance Spectroscopy
  • Mitogen-Activated Protein Kinase 14 / antagonists & inhibitors*
  • Mitogen-Activated Protein Kinase 14 / chemistry*
  • Models, Molecular*
  • Solutions
  • X-Ray Diffraction

Substances

  • 2-(2-aminophenylamino)-10,11-dihydrodibenzo(a,d)cycloheptenone
  • Cycloheptanes
  • Dibenzocycloheptenes
  • Enzyme Inhibitors
  • Solutions
  • Mitogen-Activated Protein Kinase 14