Evidence of a non-motor microlesion effect following deep brain surgery: a case report

Acta Neurochir (Wien). 2012 May;154(5):835-8. doi: 10.1007/s00701-012-1281-9. Epub 2012 Jan 28.

Abstract

We report the case of a patient who developed acute transient psychosis after implantation, but not activation of pallidal deep brain electrodes for generalised dystonia. Psychotic symptoms coincided temporally with postoperative motor improvement induced by the microlesion effect after electode implantation. This finding suggests that the microlesion effect may not be confined to motor improvement, but also comprises non-motor symptoms. In our case, affection of adjacent dopaminergic fibres of passages has to be assumed.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Deep Brain Stimulation
  • Dystonic Disorders / complications
  • Dystonic Disorders / surgery*
  • Electrodes, Implanted / adverse effects*
  • Female
  • Globus Pallidus / surgery*
  • Humans
  • Magnetic Resonance Imaging
  • Motor Activity
  • Psychotic Disorders / etiology
  • Tomography, X-Ray Computed
  • Treatment Outcome