Abstract
A 1998 investigation of an outbreak of Salmonella serotype Typhimurium infections among children tasting unpasteurized milk during tours of a dairy farm demonstrated a distribution of unusually long incubation periods (median, 8 days; interquartile range [IQR], 6-14 days). Bacterial isolates were highly acid tolerant and contained genes associated with protection against destructive phagocytic reactive oxygen intermediates. We hypothesize that exposure to low-dose oral inoculum of a pathogen with these properties could have contributed to cases of non-typhoidal salmonellosis with the longest incubation period reported to the Centers for Disease Control and Prevention (CDC).
MeSH terms
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Adolescent
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Adult
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Animals
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Centers for Disease Control and Prevention, U.S.
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Child
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Child, Preschool
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Cohort Studies
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Dairying / legislation & jurisprudence
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Disease Outbreaks*
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Feces / microbiology
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Humans
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Hydrogen-Ion Concentration
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Infant
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Infectious Disease Incubation Period*
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Legislation, Food
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Massachusetts / epidemiology
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Microbial Viability
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Middle Aged
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Milk / microbiology
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Salmonella Food Poisoning / blood
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Salmonella Food Poisoning / epidemiology*
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Salmonella Food Poisoning / microbiology
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Salmonella typhimurium / genetics
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Salmonella typhimurium / growth & development
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Salmonella typhimurium / isolation & purification*
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Salmonella typhimurium / pathogenicity*
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United States
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Young Adult