We propose that, given shared evolutionarily factors mediate vaccine response and facial development, objective, high-resolution 3D facial analysis can be employed to investigate phenomena underlying vaccine response/failure. To account for ontological processes, the optimal prospective cohort would be ascertained in early life and followed longitudinally. Additionally, the non-invasive and relatively inexpensive nature of these technologies is ideally suited for novel investigations of existing cohorts and for use in developing countries.
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