Abstract
Dosing of cefepime during high blood flow (Qb; 300 ml/min), high dialysate flow (Qd; 3 liter/h) continuous venovenous hemodialysis (CVVHD) is undefined. Six patients on CVVHD had serum and effluent cefepime concentrations measured at 0.5, 1, 2, 6, and 12 h after dosing. Three patients had cefepime concentrations less than the MIC for Pseudomonas aeruginosa. A dose of 2,000 mg every 12 h or 1,000 mg every 8 h may increase time at a therapeutic concentration.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / blood*
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Cefepime
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Cephalosporins / administration & dosage
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Cephalosporins / blood*
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Chromatography, High Pressure Liquid
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Female
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Half-Life
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Hemofiltration*
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Humans
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Kidney Failure, Chronic / blood
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Kidney Failure, Chronic / therapy
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Kidney Tubular Necrosis, Acute / therapy
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Male
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Microbial Sensitivity Tests
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Middle Aged
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Pseudomonas aeruginosa / drug effects
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Shock, Cardiogenic / therapy
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Spectrophotometry, Ultraviolet
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Young Adult
Substances
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Anti-Bacterial Agents
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Cephalosporins
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Cefepime