Advances in the understanding of the aetiology of Dupuytren's disease

Natasha E Picardo; Wasim S Khan

doi:10.1016/j.surge.2012.01.004

Advances in the understanding of the aetiology of Dupuytren's disease

Surgeon. 2012 Jun;10(3):151-8. doi: 10.1016/j.surge.2012.01.004. Epub 2012 Jan 30.

Authors

Natasha E Picardo¹, Wasim S Khan

Affiliation

¹ Royal National Orthopaedic Hospital, Stanmore, Middx HA7 4LP, UK.

PMID: 22297148
DOI: 10.1016/j.surge.2012.01.004

Abstract

Dupuytren's disease is a fibroproliferative disease of the palmar fascia which has been described for centuries, yet the aetiology and pathophysiology remain poorly understood. Surgery and collagenase injections comprise the main therapeutic options but disease recurrence is common. We explore the evidence underlying the current disease theories and outline other potential therapeutic options.

Publication types

Review

MeSH terms

Collagenases / administration & dosage*
Dupuytren Contracture / epidemiology
Dupuytren Contracture / etiology*
Dupuytren Contracture / physiopathology
Dupuytren Contracture / therapy*
Fascia / physiopathology
Female
Humans
Injections, Intralesional
Male
Orthopedic Procedures / methods*
Prognosis
Recurrence
Risk Assessment
Severity of Illness Index
Treatment Outcome

Substances

Collagenases