Innate immunity to TB: a druggable balancing act

Ajit Lalvani; Marcel A Behr; Saranya Sridhar

doi:10.1016/j.cell.2012.01.026

Innate immunity to TB: a druggable balancing act

Cell. 2012 Feb 3;148(3):389-91. doi: 10.1016/j.cell.2012.01.026.

Authors

Ajit Lalvani¹, Marcel A Behr, Saranya Sridhar

Affiliation

¹ Tuberculosis Research Unit, National Heart and Lung Institute, Imperial College London, Norfolk Place, London W2 1PG, UK. [email protected]

PMID: 22304907
DOI: 10.1016/j.cell.2012.01.026

Abstract

Tobin and colleagues show that both inhibition and excessive production of the inflammatory mediator TNFα impact the pathogenesis of tuberculosis (TB) and the response to therapy. Identifying a critical role for the genetically determined balance between pro- and anti-inflammatory eicosanoids in regulating TNFα levels provides a roadmap to tailored TB treatment based on host genotype.

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