Abstract
After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10(-9)). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10(-11).
Publication types
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Meta-Analysis
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Research Support, Non-U.S. Gov't
MeSH terms
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Case-Control Studies
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Cell Cycle Proteins
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Chromosomes, Human, Pair 11 / genetics*
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Cohort Studies
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Genetic Predisposition to Disease / genetics*
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Genetic Variation / genetics*
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Genotype
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Ghana
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Humans
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Models, Genetic
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Nuclear Proteins / genetics
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Polymorphism, Single Nucleotide / genetics
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RNA Splicing Factors
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Tuberculosis / genetics*
Substances
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Cell Cycle Proteins
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Nuclear Proteins
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RNA Splicing Factors
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WTAP protein, human