Human lymphohematopoietic reconstitution and immune function in immunodeficient mice receiving cotransplantation of human thymic tissue and CD34(+) cells

Cell Mol Immunol. 2012 May;9(3):232-6. doi: 10.1038/cmi.2011.63. Epub 2012 Feb 6.

Abstract

Small animal models with functional human lymphohematopoietic systems are highly valuable for the study of human immune function under physiological and pathological conditions. Over the last two decades, numerous efforts have been devoted towards the development of such humanized mouse models. This review is focused on human lymphohematopoietic reconstitution and immune function in humanized mice by cotransplantation of human fetal thymic tissue and CD34(+) cells. The potential use of these humanized mice in translational biomedical research is also discussed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, CD34 / metabolism
  • Fetal Tissue Transplantation*
  • Hematopoiesis*
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Immune System / cytology
  • Immune System / growth & development*
  • Mice
  • Mice, Mutant Strains
  • Thymus Gland / transplantation*
  • Translational Research, Biomedical

Substances

  • Antigens, CD34