Dual polarisation interferometry for real-time, label-free detection of interaction of mercury(II) with mercury-specific oligonucleotides

Chem Commun (Camb). 2012 Mar 18;48(23):2873-5. doi: 10.1039/c2cc16279b. Epub 2012 Feb 6.

Abstract

A real-time, label-free dual polarisation interferometry technique was used to investigate the interaction of Hg(2+) with a 21-mer T-rich oligonucleotide and further construct a Hg(2+) biosensor based on thymine-Hg(2+)-thymine coordination chemistry.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biosensing Techniques*
  • Circular Dichroism
  • Interferometry*
  • Mercury / chemistry*
  • Oligonucleotides / chemistry*
  • Polyethyleneimine / chemistry
  • Thymine / chemistry

Substances

  • Oligonucleotides
  • Polyethyleneimine
  • Mercury
  • Thymine