Screening for chemicals that affect hair cell death and survival in the zebrafish lateral line

Hear Res. 2012 Jun;288(1-2):58-66. doi: 10.1016/j.heares.2012.01.009. Epub 2012 Jan 31.

Abstract

The zebrafish lateral line is an efficient model system for the evaluation of chemicals that protect and damage hair cells. Located on the surface of the body, lateral line hair cells are accessible for manipulation and visualization. The zebrafish lateral line system allows rapid screens of large chemical libraries, as well as subsequent thorough evaluation of interesting compounds. In this review, we focus on the results of our previous screens and the evolving methodology of our screens for chemicals that protect hair cells, and chemicals that damage hair cells using the zebrafish lateral line.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Death / drug effects
  • Cell Survival / drug effects
  • Cytoprotection
  • Hair Cells, Auditory, Inner / drug effects*
  • Hair Cells, Auditory, Inner / pathology
  • Lateral Line System / drug effects*
  • Lateral Line System / pathology
  • Mass Screening / methods*
  • Neuroprotective Agents / pharmacology*
  • Toxicity Tests / methods*
  • Zebrafish*

Substances

  • Neuroprotective Agents