Palladium-catalyzed direct hydroxymethylation of aryl halides and triflates with potassium acetoxymethyltrifluoroborate

Norio Murai; Masahiro Yonaga; Keigo Tanaka

doi:10.1021/ol300149b

Palladium-catalyzed direct hydroxymethylation of aryl halides and triflates with potassium acetoxymethyltrifluoroborate

Org Lett. 2012 Mar 2;14(5):1278-81. doi: 10.1021/ol300149b. Epub 2012 Feb 9.

Authors

Norio Murai¹, Masahiro Yonaga, Keigo Tanaka

Affiliation

¹ Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Tokyo 113-0033, Japan.

PMID: 22320424
DOI: 10.1021/ol300149b

Abstract

Suzuki-Miyaura cross-coupling reactions of aryl halides and triflates with potassium acetoxymethyltrifluoroborate afforded the corresponding aryl and heteroaryl methanol products in moderate to excellent yields.

MeSH terms

Bromine Compounds / chemistry*
Catalysis
Chlorine Compounds / chemistry*
Hydrogenation
Ligands
Mesylates / chemistry*
Methylation
Molecular Structure
Organometallic Compounds / chemistry*
Palladium / chemistry*
Potassium

Substances

Bromine Compounds
Chlorine Compounds
Ligands
Mesylates
Organometallic Compounds
potassium acetoxymethyltrifluoroborate
Palladium
trifluoromethanesulfonic acid
Potassium