Atypical granular cell tumor occurring in an individual with Noonan syndrome treated with growth hormone

D Moos; C Droitcourt; D Rancherevince; P Marec Berard; F Skowron

doi:10.1111/j.1525-1470.2011.01641.x

Atypical granular cell tumor occurring in an individual with Noonan syndrome treated with growth hormone

Pediatr Dermatol. 2012 Sep-Oct;29(5):665-6. doi: 10.1111/j.1525-1470.2011.01641.x. Epub 2012 Feb 14.

Authors

D Moos¹, C Droitcourt, D Rancherevince, P Marec Berard, F Skowron

Affiliation

¹ Dermatology Service, Centre Hospitalier de Valence, Valence, France.

PMID: 22329457
DOI: 10.1111/j.1525-1470.2011.01641.x

Abstract

We report a large infiltrating atypical granular cell tumor in a child with Noonan syndrome. Even though granular cell tumors are rare in childhood, five cases have been reported in children with Noonan syndrome. This study compares these different cases and explores the possibility of activation of the granular cell by the Ras pathway.

Publication types

Case Reports

MeSH terms

Child
Female
Granular Cell Tumor / diagnosis*
Granular Cell Tumor / genetics
Granular Cell Tumor / pathology
Granular Cell Tumor / surgery
Human Growth Hormone / therapeutic use*
Humans
Mutation
Noonan Syndrome / drug therapy*
Noonan Syndrome / genetics
Protein Tyrosine Phosphatase, Non-Receptor Type 11 / genetics
Treatment Outcome

Substances

Human Growth Hormone
PTPN11 protein, human
Protein Tyrosine Phosphatase, Non-Receptor Type 11