XmAb-5574 antibody demonstrates superior antibody-dependent cellular cytotoxicity as compared with CD52- and CD20-targeted antibodies in adult acute lymphoblastic leukemia cells

Leukemia. 2012 Jul;26(7):1720-2. doi: 10.1038/leu.2012.40. Epub 2012 Feb 15.
No abstract available

Publication types

  • Comparative Study
  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibodies, Monoclonal / pharmacology*
  • Antibody-Dependent Cell Cytotoxicity*
  • Antigens, CD / immunology*
  • Antigens, CD19 / immunology*
  • Antigens, CD20 / immunology*
  • Antigens, Neoplasm / immunology*
  • CD52 Antigen
  • Flow Cytometry
  • Glycoproteins / immunology*
  • Humans
  • Immunoglobulin Fc Fragments / immunology*
  • Immunoglobulin Fc Fragments / metabolism
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • Receptors, IgG / immunology
  • Receptors, IgG / metabolism

Substances

  • Antibodies, Monoclonal
  • Antigens, CD
  • Antigens, CD19
  • Antigens, CD20
  • Antigens, Neoplasm
  • CD52 Antigen
  • CD52 protein, human
  • Fc gamma receptor IIB
  • Glycoproteins
  • Immunoglobulin Fc Fragments
  • Receptors, IgG