Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines

J Antibiot (Tokyo). 2012 May;65(5):263-5. doi: 10.1038/ja.2012.6. Epub 2012 Feb 15.
No abstract available

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Azepines / chemistry
  • Azepines / pharmacology
  • Crystallization
  • Disulfides / pharmacology
  • Drug Design
  • Enzyme Inhibitors / pharmacology*
  • Gliotoxin / chemistry
  • Gliotoxin / pharmacology*
  • Histone Methyltransferases
  • Histone-Lysine N-Methyltransferase / antagonists & inhibitors*
  • Indole Alkaloids / pharmacology
  • Methylation / drug effects
  • Piperazines / chemistry
  • Piperazines / pharmacology*
  • Quinazolines / chemistry
  • Quinazolines / pharmacology

Substances

  • Azepines
  • BIX 01294
  • Disulfides
  • Enzyme Inhibitors
  • Indole Alkaloids
  • Piperazines
  • Quinazolines
  • chetomin
  • chaetocin
  • Gliotoxin
  • Histone Methyltransferases
  • Histone-Lysine N-Methyltransferase
  • 11,11'-dideoxyverticillin A