TEMPO-mediated electrooxidation of primary and secondary alcohols in a microfluidic electrolytic cell

ChemSusChem. 2012 Feb 13;5(2):326-31. doi: 10.1002/cssc.201100601.

Abstract

A general procedure for the 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-mediated electrooxidation of primary and secondary alcohols modified for application in a microfluidic electrolytic cell is described. The electrocatalytic system utilises a buffered aqueous tert-butanol reaction medium, which operates effectively without the requirement for additional electrolyte, providing a mild protocol for the oxidation of alcohols to aldehydes and ketones at ambient temperature on a laboratory scale. Optimisation of the process is discussed along with the oxidation of 15 representative alcohols.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohols / chemistry*
  • Cyclic N-Oxides / chemistry*
  • Electrochemistry
  • Electrolysis / instrumentation*
  • Green Chemistry Technology / instrumentation*
  • Hydrogen-Ion Concentration
  • Microfluidic Analytical Techniques / methods*
  • Oxidation-Reduction
  • Temperature

Substances

  • Alcohols
  • Cyclic N-Oxides
  • TEMPO