Pharmacokinetics and administration method of gentamicin in a patient on haemodialysis

Yoichi Hiraki; Mikako Hiraike; Masahisa Nagano; Yukari Ozono; Kenichi Manabe; Nobuhiro Misumi; Yasuhiro Tsuji; Hidetoshi Kamimura; Yoshiharu Karube

doi:10.3109/00365548.2012.655774

Pharmacokinetics and administration method of gentamicin in a patient on haemodialysis

Scand J Infect Dis. 2012 Aug;44(8):630-4. doi: 10.3109/00365548.2012.655774. Epub 2012 Feb 19.

Authors

Yoichi Hiraki¹, Mikako Hiraike, Masahisa Nagano, Yukari Ozono, Kenichi Manabe, Nobuhiro Misumi, Yasuhiro Tsuji, Hidetoshi Kamimura, Yoshiharu Karube

Affiliation

¹ Department of Pharmacy, National Hospital Organization Kumamoto Medical Center, Kumamoto City, Kumamoto, Japan. [email protected]

PMID: 22339591
DOI: 10.3109/00365548.2012.655774

Abstract

We investigated the pharmacokinetics of gentamicin in a haemodialysis patient treated for endocarditis caused by methicillin-resistant Staphylococcus aureus and found that the administration of gentamicin immediately prior to dialysis was a suitable strategy for reaching target maximum drug concentration (Cmax) values and low trough levels.

Publication types

Case Reports

MeSH terms

Aged, 80 and over
Anti-Bacterial Agents / administration & dosage*
Anti-Bacterial Agents / blood
Anti-Bacterial Agents / pharmacokinetics*
Endocarditis, Bacterial / drug therapy
Endocarditis, Bacterial / metabolism
Endocarditis, Bacterial / microbiology
Female
Gentamicins / administration & dosage*
Gentamicins / blood
Gentamicins / pharmacokinetics*
Humans
Methicillin-Resistant Staphylococcus aureus / isolation & purification
Renal Dialysis*
Staphylococcal Infections / drug therapy
Staphylococcal Infections / metabolism

Substances

Anti-Bacterial Agents
Gentamicins