Effect of orange peel essential oil on oxidative stress in AOM animals

Int J Biol Macromol. 2012 May 1;50(4):1144-50. doi: 10.1016/j.ijbiomac.2012.02.002. Epub 2012 Feb 10.

Abstract

The processing parameters of pump speed, inlet air temperature, outlet air temperature and homogenization pressure were evaluated. Encapsulation efficiency is high with a satisfied releasing rate. Then, acute otitis media (AOM) animal model was built and diet containing orange peel essential oil microcapsules were administrated to AOM animals. Pharmacological test showed that orange peel essential oil treatment could decrease serum and cochlea malondialdehyde (MDA), immunoglobulins A (IgA), immunoglobulins G (IgG), immunoglobulins M (IgM) levels and increase antioxidant enzymes activities. It can be concluded that orange peel essential oil treatment could decrease oxidative injury in acute otitis media rats.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Animals
  • Capsules
  • Citrus sinensis / chemistry*
  • Glutathione / metabolism
  • Immunoglobulins / metabolism
  • Male
  • Malondialdehyde / metabolism
  • Oils, Volatile / pharmacology*
  • Otitis Media / immunology
  • Otitis Media / metabolism*
  • Oxidative Stress / drug effects*
  • Plant Epidermis / chemistry
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Capsules
  • Immunoglobulins
  • Oils, Volatile
  • Malondialdehyde
  • Glutathione