A novel phytotoxic nonenolide from Phomopsis sp. HCCB03520

Chem Biodivers. 2012 Feb;9(2):403-8. doi: 10.1002/cbdv.201100080.

Abstract

A novel phytotoxic nonenolide, (6S,7R,9R)-6,7-dihydroxy-9-propylnon-4-eno-9-lactone (1), was isolated from solid cultures of the endophytic fungus Phomopsis sp. HCCB03520, together with three known compounds, cytochalasin H (2), cytochalasin N (3), and epoxycytochalasin H (4). The structures of these compounds were elucidated through spectroscopic analysis, and the absolute configurations were determined by CD spectroscopy. Phytotoxic activities of compounds 1-4 were also investigated. Compound 1 showed phytotoxic activity on germination and radicle growth of Medicago sativa, Trifolium hybridum, and Buchloe dactyloides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ascomycota / chemistry*
  • Germination / drug effects*
  • Heterocyclic Compounds, 1-Ring / chemistry
  • Heterocyclic Compounds, 1-Ring / isolation & purification*
  • Heterocyclic Compounds, 1-Ring / pharmacology*
  • Lactones / chemistry
  • Lactones / isolation & purification*
  • Lactones / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Medicago sativa / drug effects*
  • Medicago sativa / growth & development
  • Molecular Structure
  • Plant Roots / chemistry
  • Plant Roots / drug effects
  • Poaceae / drug effects*
  • Poaceae / growth & development
  • Seeds / chemistry
  • Seeds / drug effects
  • Trifolium / drug effects*
  • Trifolium / growth & development

Substances

  • 6,7-dihydroxy-9-propylnon-4-eno-9-lactone
  • Heterocyclic Compounds, 1-Ring
  • Lactones