Abstract
The limited availability of approved influenza virus antivirals highlights the importance of studying the fitness and transmissibility of drug-resistant viruses. S247N is a novel, naturally occurring N1 neuraminidase mutation that reduces oseltamivir sensitivity and greatly potentiates oseltamivir resistance in the context of the H275Y mutation. Here we show that highly oseltamivir-resistant viruses containing both the S247N and H275Y mutations transmit efficiently in the guinea pig transmission model.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Substitution
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Animals
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Antiviral Agents / pharmacology*
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Cell Line
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Dogs
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Drug Resistance, Viral / genetics
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Guinea Pigs
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Influenza A Virus, H1N1 Subtype / drug effects*
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Influenza A Virus, H1N1 Subtype / enzymology
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Influenza A Virus, H1N1 Subtype / genetics*
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Mutation
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Neuraminidase / genetics
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Neuraminidase / metabolism
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Orthomyxoviridae Infections / transmission*
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Oseltamivir / pharmacology*
Substances
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Antiviral Agents
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Oseltamivir
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Neuraminidase