The UL36 tegument protein of herpes simplex virus 1 has a composite binding site at the capsid vertices

J Virol. 2012 Apr;86(8):4058-64. doi: 10.1128/JVI.00012-12. Epub 2012 Feb 15.

Abstract

Herpesviruses have an icosahedral nucleocapsid surrounded by an amorphous tegument and a lipoprotein envelope. The tegument comprises at least 20 proteins destined for delivery into the host cell. As the tegument does not have a regular structure, the question arises of how its proteins are recruited. The herpes simplex virus 1 (HSV-1) tegument is known to contact the capsid at its vertices, and two proteins, UL36 and UL37, have been identified as candidates for this interaction. We show that the interaction is mediated exclusively by UL36. HSV-1 nucleocapsids extracted from virions shed their UL37 upon incubation at 37°C. Cryo-electron microscopy (cryo-EM) analysis of capsids with and without UL37 reveals the same penton-capping density in both cases. As no other tegument proteins are retained in significant amounts, it follows that this density feature (∼100 kDa) represents the ordered portion of UL36 (336 kDa). It binds between neighboring UL19 protrusions and to an adjacent UL17 molecule. These observations support the hypothesis that UL36 plays a major role in the tegumentation of the virion, providing a flexible scaffold to which other tegument proteins, including UL37, bind. They also indicate how sequential conformational changes in the maturing nucleocapsid control the ordered binding, first of UL25/UL17 and then of UL36.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural

MeSH terms

  • Binding Sites
  • Capsid Proteins / chemistry*
  • Capsid Proteins / metabolism
  • Herpesvirus 1, Human / chemistry*
  • Herpesvirus 1, Human / metabolism
  • Herpesvirus 1, Human / ultrastructure
  • Models, Molecular
  • Nucleocapsid / chemistry
  • Nucleocapsid / ultrastructure
  • Viral Proteins / chemistry*
  • Viral Proteins / metabolism
  • Virion / chemistry

Substances

  • Capsid Proteins
  • UL36 protein, Human herpesvirus 1
  • Viral Proteins