A DTTA-ligated uridine-quantum dot conjugate as a bimodal contrast agent for cellular imaging

Chem Commun (Camb). 2012 Mar 28;48(26):3218-20. doi: 10.1039/c2cc17555j. Epub 2012 Feb 20.

Abstract

A uridine-quantum dot conjugate, a contrast agent for multimodal imaging, was synthesized. Its T(1) relaxivity was 655 and 571.2 mM(-1) s(-1) per particle at 36 °C in phosphate buffered saline at 60 and 200 MHz, respectively. In vitro multimodal images confirmed its uptake by RAW 264.7 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Contrast Media* / chemical synthesis
  • Contrast Media* / chemistry
  • Flow Cytometry
  • Gadolinium / chemistry
  • Magnetic Resonance Imaging
  • Mice
  • Microscopy, Fluorescence
  • Molecular Structure
  • Neoplasms / diagnosis*
  • Organometallic Compounds* / chemical synthesis
  • Organometallic Compounds* / chemistry
  • Quantum Dots*
  • Uridine / chemistry*

Substances

  • Contrast Media
  • Organometallic Compounds
  • Gadolinium
  • Uridine