Abstract
We report a lateral rectus muscle paralysis occurring 2 weeks after initiation of an interferon-α and ribavirin treatment in a patient with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) virus co-infection. This patient presented with horizontal diplopia that appeared rapidly and without any other neurological symptoms. Symptoms fully resolved with treatment interruption without any ophthalmological sequelae. This side effect is rare and has never been reported in a HIV-HCV co-infected patient.
MeSH terms
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Abducens Nerve Diseases / chemically induced*
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Abducens Nerve Diseases / diagnosis
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Adult
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Antiviral Agents / adverse effects*
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Antiviral Agents / therapeutic use
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Eye / drug effects
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Eye / physiopathology
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HIV Infections / drug therapy*
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HIV Infections / virology
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Hepatitis C, Chronic / drug therapy*
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Hepatitis C, Chronic / virology
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Humans
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Interferon-alpha / adverse effects*
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Interferon-alpha / therapeutic use
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Male
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Muscle, Skeletal / drug effects
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Muscle, Skeletal / physiopathology
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Polyethylene Glycols / adverse effects*
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Polyethylene Glycols / therapeutic use
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Recombinant Proteins / adverse effects
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Recombinant Proteins / therapeutic use
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Ribavirin / adverse effects*
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Ribavirin / therapeutic use
Substances
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Antiviral Agents
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Interferon-alpha
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Recombinant Proteins
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Polyethylene Glycols
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Ribavirin
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peginterferon alfa-2a