Abstract
Berberine is an isoquinoline alkaloid isolated from Chinese herbs such as Coptidis Rhizome. This paper is a systematic review of the structural modifications of berberine for different biological activities such as antitumor, antimicrobial, anti-Alzheimer's disease, antihyperglycemic, anti-inflammatory and antimalaria. The current review would provide some useful information for further studies on structural modification of berberine for discovering new drug leads.
Publication types
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Research Support, Non-U.S. Gov't
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Review
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Systematic Review
MeSH terms
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Alzheimer Disease / drug therapy
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Animals
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / pharmacology
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / pharmacology
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Antimalarials / chemistry
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Antimalarials / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Bacterial Infections / drug therapy
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Berberine / chemistry*
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Berberine / pharmacology*
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Coptis chinensis
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Diabetes Mellitus / drug therapy
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Drug Discovery* / methods
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Drugs, Chinese Herbal / chemistry*
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Drugs, Chinese Herbal / pharmacology*
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Humans
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Hypoglycemic Agents / chemistry
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Hypoglycemic Agents / pharmacology
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Malaria / drug therapy
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Medicine, Chinese Traditional
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Mycoses / drug therapy
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Neoplasms / drug therapy
Substances
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Anti-Infective Agents
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Anti-Inflammatory Agents
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Antimalarials
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Antineoplastic Agents
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Drugs, Chinese Herbal
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Hypoglycemic Agents
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Berberine
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Coptidis rhizoma extract