Abstract
In patients with deficient immune defenses, a localized oral infection can progress to a systemic infection. The purpose of this paper was to describe the case of a child with acute lymphoblastic leukemia who presented with fever, trismus, and submandibular swelling in the absence of the typical dental causes of infection such as deep dental caries or clinically significant periodontal disease. Treatment included an aggressive intravenous antibiotic regimen and extraction of the offending tooth after the recovery from bone marrow suppression.
MeSH terms
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Anti-Bacterial Agents / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Cefepime
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Cephalosporins / administration & dosage
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Child
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Clindamycin / administration & dosage
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Drug Combinations
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Female
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Focal Infection, Dental / complications
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Focal Infection, Dental / drug therapy
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Focal Infection, Dental / etiology*
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Humans
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Injections, Intravenous
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Mercaptopurine / administration & dosage
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Methotrexate / administration & dosage
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Neutropenia / complications
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology
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Tooth Exfoliation*
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Tooth Extraction
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Tooth, Deciduous / microbiology
Substances
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Anti-Bacterial Agents
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Cephalosporins
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Drug Combinations
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Clindamycin
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Cefepime
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Mercaptopurine
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Methotrexate