On the mode of action ofClostridium difficile toxin A: anin vitro study

C Fiorentini; G Donelli; P Nicotera; P Mastrantonio; M Thelestam

doi:10.1007/BF00736818

On the mode of action ofClostridium difficile toxin A: anin vitro study

Cytotechnology. 1991 Feb;5(Suppl 1):84-5. doi: 10.1007/BF00736818.

Authors

C Fiorentini¹, G Donelli, P Nicotera, P Mastrantonio, M Thelestam

Affiliation

¹ Lab. Ultrastrutture, Istituto Superiore di Sanita', Viale Regina Elena 299, 00161, Roma, Italy.

PMID: 22358964
DOI: 10.1007/BF00736818

Abstract

C. difficile toxin A causes the rounding up and the formation of surface blebs in normal rat intestinal crypt cells (IEC-6). These phenomena, together with the inhibition of DNA synthesis and the cell lysis, could be the mechanisms leading the toxin-treated cells to death.