Histopathologic approach to the surgical lung biopsy in interstitial lung disease

Clin Chest Med. 2012 Mar;33(1):27-40. doi: 10.1016/j.ccm.2012.01.003.

Abstract

Interpretation of lung biopsy specimens is an integral part in the diagnosis of interstitial lung disease (ILD). The process of evaluating a surgical lung biopsy for disease involves answering several questions. Unlike much of surgical pathology of neoplastic lung disease, arriving at the correct diagnosis in nonneoplastic lung disease often requires correlation with clinical and radiologic findings. The topic of ILD or diffuse infiltrative lung disease covers several hundred entities. This article is meant to be a launching point in the clinician's approach to the histologic evaluation of lung disease.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Biopsy / methods*
  • Bronchiolitis Obliterans / pathology*
  • Bronchiolitis Obliterans / surgery
  • Diagnosis, Differential
  • Granuloma / pathology
  • Humans
  • Hypertension, Pulmonary / pathology*
  • Hypertension, Pulmonary / surgery
  • Idiopathic Interstitial Pneumonias / pathology
  • Idiopathic Interstitial Pneumonias / surgery
  • Lung / anatomy & histology
  • Lung / pathology*
  • Lung / surgery
  • Lung Diseases, Interstitial / pathology*
  • Lung Diseases, Interstitial / surgery
  • Lung Injury / pathology
  • Pulmonary Fibrosis / pathology*
  • Pulmonary Fibrosis / surgery