Peripheral human γδ T cells control growth of both avirulent and highly virulent strains of Francisella tularensis in vitro

Caroline A Rowland; M Gill Hartley; Helen Flick-Smith; Thomas R Laws; Jim E Eyles; Petra C F Oyston

doi:10.1016/j.micinf.2012.02.001

Peripheral human γδ T cells control growth of both avirulent and highly virulent strains of Francisella tularensis in vitro

Microbes Infect. 2012 Jul;14(7-8):584-9. doi: 10.1016/j.micinf.2012.02.001. Epub 2012 Feb 11.

Authors

Caroline A Rowland¹, M Gill Hartley, Helen Flick-Smith, Thomas R Laws, Jim E Eyles, Petra C F Oyston

Affiliation

¹ Biomedical Sciences Dept, Dstl, Porton Down, Salisbury SP4 0JQ, UK. [email protected]

PMID: 22370220
DOI: 10.1016/j.micinf.2012.02.001

Abstract

In this paper we evaluate the role of human γδ T cells in control of Francisella tularensis infection. Using an in vitro model of infection, a reduction in bacterial numbers was detected in the presence of human γδ T cells for both attenuated LVS and virulent SCHU S4 strains of F. tularensis. Antibody neutralisation of IFN-γ caused an increase in survival of F. tularensis LVS suggesting that γδ T cell-mediated control of F. tularensis infection is partially mediated by IFN-γ.

MeSH terms

Cells, Cultured
Francisella tularensis / classification
Francisella tularensis / immunology*
Francisella tularensis / pathogenicity*
Humans
Interferon gamma Receptor
Receptors, Antigen, T-Cell, gamma-delta / immunology*
Receptors, Interferon / metabolism
Species Specificity
T-Lymphocytes / immunology*
Tularemia / immunology*
Tularemia / microbiology*

Substances

Receptors, Antigen, T-Cell, gamma-delta
Receptors, Interferon